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CBD as an Alternative to Treating Depression: An In-depth Look



CBD as an alternative to treating depression

Key takeaway's

  • “CBD as an Alternative to Treating Depression” reveals exciting insights into how CBD, a natural substance, may alleviate depressive symptoms by modulating serotonin levels, a function similar to many antidepressants.
  • The article dives into research indicating that high-CBD and low-THC products could provide meaningful relief from depression, potentially offering a refreshing and natural alternative to traditional treatments.
  • Finally, the need for further research is recognized not as a limitation, but as an exciting opportunity for future breakthroughs in establishing CBD's role in treating depression, including optimal dosage guidelines.
    CBD alternative

Understanding CBD

In the ever-evolving health and wellness industry, CBD, or Cannabidiol, has become increasingly prominent for its potential therapeutic applications. Among the myriad of proposed benefits, the concept of CBD as an Alternative to Treating Depression has generated significant interest.

What is CBD?

Cannabidiol (CBD) is one of over 400 chemicals found in the Cannabis sativa plant, also referred to as hemp or marijuana. It shares this botanical home with another famous chemical, Tetrahydrocannabinol (THC), widely known for its intoxicating effects.


Despite their common origin, CBD and THC differ substantially in their effects. THC is associated with euphoria, relaxation, and increased appetite, while CBD is known for inducing relaxation and pain relief without causing an intoxicating “high”.


CBD's Potential Role in Mental Health

Research has suggested CBD's role in treating several medical conditions, such as cancer, chronic pain, epilepsy, Parkinson's disease, Alzheimer's disease, and mental health conditions including anxiety disorders, addiction, schizophrenia, and insomnia.

The Legality of CBD

Following the 2018 Farm Bill, selling hemp products like CBD became legal in the United States, albeit with certain restrictions. Notably, CBD products should contain less than .03% THC. Currently, Epidiolex is the only FDA-approved CBD medication, intended for treating severe forms of epilepsy.

CBD as an Alternative to Treating Depression

Emerging evidence suggests that CBD may influence serotonin levels in the brain, a neurotransmitter vital for mood regulation. This effect is similar to how selective serotonin reuptake inhibitors (SSRIs), a class of antidepressants, function.CBD mental health

Can CBD Help with Depression?

While CBD may aid in managing depression, it can interfere with other medications and potentially cause side effects. Thus, it's crucial to consult a healthcare professional before starting a CBD regimen.

Research on CBD and Depression

Several studies have explored the efficacy of CBD for depression:

  1. A 2019 study found CBD reduced helplessness in rats, a common depression symptom.
  2. A 2020 study reported CBD decreased symptoms of depression and anhedonia (inability to experience pleasure) in rats.
  3. A 2018 study noted a high concentration of CBD (>9.5%) and a low concentration of THC (<5.5%) yielded the largest improvements in depression.
  4. A 2019 case study showed CBD treatment reduced depression and anxiety symptoms in a patient with multiple substance use disorders.

Safety and Side Effects of CBD

Generally, CBD is considered safe. However, it may cause side effects like dry mouth, low blood pressure, drowsiness, and lightheadedness. It's advised for certain individuals, including pregnant or breastfeeding women and people with liver disease, to avoid CBD.

Consuming CBD for Mental Health Benefits

CBD can be consumed in various forms, including oils, vapor, nasal sprays, capsules, edibles, and creams. Products with a high concentration of CBD (>9.5%) and a low THC concentration (<5.5%) are considered most beneficial for depression.

CBD and Antidepressants

For individuals on antidepressants, using CBD products simultaneously may be safe under healthcare provider's guidance. However, CBD is not recommended for those on carbamazepine (Tegretol), an anti-seizure medication, due to potential increased side effects.

The Risk of Addiction to CBD

Pure CBD is not considered addictive. According to the World Health Organization, there's no evidence that CBD can cause misuse or dependence. However, since CBD products may contain THC, which can be addictive, it's vital to use these products responsibly and under professional advice.

Where to Buy CBD Online

Pure Spectrum CBD

pure spectrum

Established in 2015, Pure Spectrum CBD is an online CBD store that serves customers throughout America and offers free shipping for orders over $100.

Their product range comes in four categories: pure CBD and CBDA isolates, tinctures, hemp seed oil, and CBD for pets. All their CBD products are hemp based and contain less than 0.3% THC, which means that they are not intoxicating. The company is committed to organic cultivation practices and high processing standards including third-party testing.



Established in 2019, Kanibi is an online CBD store that's committed to “raising the bar” on CBD standards. Their product range is diverse, even including CBD chewing gum and sports creams. They also offer high potency CBD up to 1,500 mgs. All their CBD products are made from hemp that is grown in the US using organic practices.

They believe that CBD manufacturing process should be transparent, meaning they double-test every single one of their products never contain artificial colors, flavors, sweeteners,  or dyes. To top things off they offer free shipping on domestic orders exceeding $100.



Established in 2018, Zatural was started by a naturopathic doctor and offers CBD products in three categories: recovery & relief, mood support, and sleep. They go the extra mile to offer free shipping on domestic orders over $5. This company has been featured on several reputable media outlets including WebMD, Men’s Journal, US Weekly, and Ministry of Hemp. What we love most about this company is the extensive and creative product range.

Zatural's extensive list of products is sourced from trusted sources here in the U.S. and worldwide. Each product is organically grown and is free from harmful chemicals and additives. Zatural products are third-party tested to ensure each product is safe.


The potential of CBD as an alternative to treating depression appears promising. While CBD is generally considered safe and non-addictive, it can induce side effects and interact with certain medications. Always consult with a healthcare professional before starting a CBD regimen for safe and effective mental health management.

Yan is a music teacher who's passionate about exploring the world of cannabis and all the amazing benefits it has to offer. You can catch him jamming out to his favorite tunes while immersing himself in the wonders of this incredible plant whenever he can.